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. 2021 Feb 18;8:618574. doi: 10.3389/fcell.2020.618574

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Copyright © 2021 Cheng, Wang, Wu, Cui, Wei, Liu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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circPostn promotes H/R-induced cardiomyocyte injury by modulating miR-96-5p/BNIP3 axis (Rzem et al., 2007). The H/R-treated AC16 cells were treated with circPostn shRNA or co-treated with circPostn shRNA and miR-96-5p inhibitor or BNIP3 overexpression vector. (A) The cell viability was measured by CCK-8 assays in the cells. (B,C) Cell apoptosis was analyzed by flow cytometry in the cells. Mean ± SD of at least three experiments was shown. Statistically significant differences were indicated: *p < 0.05, **p < 0.01.