Table 4.

Questionnaire Scores.

	Interval	Difference in means (95% CI)	P Value
Fatigue	0–12M	−3.854 (−7.575 – −0.133)	0.05
	0–24M	−3.136 (−7.198 – 0.927)	0.13
Quality of Life
Symptoms	0–12M	0.156 (−2.494 – 2.806)	0.91
	0–24M	0.368 (−2.527 – 3.262)	0.80
Functional	0–12M	−1.537 (−4.692 – 1.618)	0.34
	0–24M	−0.703 (−4.150 – 2.743)	0.70
Global Health	0–12M	−3.829 (−8.087 – 0.428)	0.08
	0–24M	−3.800 (−8.451 – 0.850)	0.11
LC13	0–12M	1.246 (−1.047 – 3.539)	0.29
	0–24M	0.637 (−1.875 – 3.150)	0.62
Sleep
Sleep Adequacy	0–12M	−3.536 (−8.986 – 1.195)	0.20
	0–24M	−4.057 (−9.975 – 1.862)	0.18
Sleep Problems Index II	0–12M	1.215 (−1.920 – 4.350)	0.48
	0–24M	1.440 (−1.968 – 4.847)	0.40

Scores represent a difference of means. Mean scores not shown. Fatigue scores calculated using the Multidimensional Fatigue Index 20 questionnaire. QoL calculated using the EORCT QLQ C30 and LC13 questionnaires. Sleep scores calculated using the MOS Sleep Survey. See Appendix 2.0 “Questionnaire Scoring Algorithms” for information on how questionnaires were scored. Melatonin (N = 356); Placebo (N = 353).