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. 2021 Feb 18;9:631272. doi: 10.3389/fcell.2021.631272

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Copyright © 2021 Huang, Yin, Xu, Fei, Heng, Jiang, Chen and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of tendon hierarchical structure and various subpopulations of TSPCs with specific markers harvested from different niches, including tendon proper, peritenon and perivascular region. Tenocytes are aligned between fibers. It should be noted that some of these subpopulations might overlap with each other and perivascular TSPCs may be present in endotenon as well as the peritenon. What’s more, the exact location of proper-derived TSPCs is not well determined. Figures were produced using Servier Medical Art (https://smart.servier.com/).