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. 2021 Feb 18;12:641562. doi: 10.3389/fimmu.2021.641562

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Copyright © 2021 Zhang, Kuang, Li, Li, Feng, Lyu, Huang, Lian, Yang, Hu, Xie, Xue and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-18 regulates the inflammatory reaction of periodontal ligament cells in vitro. Periodontal ligament cells were isolated from five healthy individuals who underwent routine premolar procedures for orthodontic reasons and were stimulated with recombinant human IL-18 for 48 h. (A) Proliferation of periodontal ligament cells was measured by Cell Counting Kit-8. (B) Cell cycle and apoptosis was assessed by flow cytometry. Expression of (C) Interferon-γ (IFN-γ), (D) granulocyte macrophage-colony stimulating factor (GM-CSF), (E) IL-2, and (F) tumor necrosis factor-α (TNF-α) was measured by ELISA. Data are expressed as mean ± standard deviation. Group differences were assessed by paired t-test.