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. 2021 Feb 18;9:639851. doi: 10.3389/fcell.2021.639851

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Copyright © 2021 Zhao, Gao, Liang, Chen, Wang, Wang, Xiao, Zhao, Wan, Jiang, Luo, Wang and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of SLC7A11 inhibitor on ARPE cell line. (A) The GSH of ARPE19 with different concentration of SAS (n = 5). (B) The concentration of VEGF of ARPE19 with SAS stimulation by ELISA (n = 5). (C,D) The protein expression of GPX4 with different concentration of SAS (n = 3). (E) The cell viability of ARPE19 with different concentration of SAS (n = 5). (F,G) The cell viability of ARPE19 with treatment of Fer-1 (1000 nM) or Lip-1 (20 μM) after stimulation of 1600 μM SAS (n = 6). (H–J) The level of lipid peroxidation under SAS stimulation by BODIPY^TM 581/591 (n = 5). Bar graphs show mean ± SD. P-values: one-way ANOVA analysis and t-test (***p < 0.001, **p < 0.01, *p < 0.05). Scale bar = 50 μm.