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. 2021 Feb 18;12:633696. doi: 10.3389/fmicb.2021.633696

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Copyright © 2021 Barroso, Gropillo, Detoni, Thompson-Souza, Muniz, Vasconcelos, Figueiredo, Melo and Neves.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(1) A. fumigatus conidia-human eosinophil interaction triggers the activation of Src that will phosphorylate Syk tyrosine kinases. Then, PI3δK will be activated followed by Akt, probably with the participation of calcium. p38 MAPK will also likely be activated downstream the PI3K signaling (2) This signaling leads to histone citrullination mediated by PAD4 and chromatin decondensation. However, PAD4 and H3 citrullination are not essential for EETs extrusion. (3) Rupture of the nuclear envelope and plasma membrane allowed the release of chromatin-formed EETs that entrap A. fumigatus conidia and free extracellular granules (FEGs).