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. 2021 Feb 18;9:637309. doi: 10.3389/fcell.2021.637309

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Copyright © 2021 Sun, Fu, Ma and Hutchins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chromatin reconfiguration in the reprogramming of somatic cells to induced pluripotent stem cells. OSKM transgenes are transfected into somatic cells and initiate a complex series of biological programs, including the suppression of the somatic program in the early phase of reprogramming and the activation of the pluripotent program in the late phase. Transient waves of gene expression programs occur between the two-cell type states. Chromatin is remodeled throughout the reprogramming process, and especially at somatic loci and pluripotent gene loci that open and close chromatin and lose or gain histone methylation.