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. 2020 Nov 25;26(3):e367–e373. doi: 10.1002/onco.13582
Drug 1
Generic/Working Name PHY906, KD018, YIV‐906
Trade Name YIV‐906
Company Name Yiviva Inc.
Dose 800 b.i.d. milligrams (mg) per day
Route Oral (p.o.)
Schedule of Administration Patients were initially treated for two 21‐day courses with PHY906 800 mg b.i.d. + capecitabine 750 mg/m2 b.i.d. according to the following schedule: capecitabine 14 days on treatment, days 1 through 14, and 7 days off treatment; PHY906 days 1 through 4 and days 8 through 11 of each course. Patients might remain on study beyond their initial two courses of treatment until tumor progression or unacceptable toxicity mandated their removal.
Drug 2
Generic/Working Name Xeloda
Trade Name Capecitabine
Company Name Roche
Dose 750 milligrams (mg) per squared meter (m2)
Route Oral (p.o.)
Schedule of Administration Patients were initially be treated for two 21‐day courses with PHY906 800 mg b.i.d. + capecitabine 750 mg/m2 b.i.d. according to the following schedule: capecitabine 14 days on treatment and 7 days off treatment and PHY906 days 1 through 4 and days 8 through 11 of each course. Patients might remain on study beyond their initial two courses of treatment until tumor progression or unacceptable toxicity mandated their removal.