Table 2.
Treatment‐related adverse events (n = 67)
| Adverse event a | Grade 2, n (%) | Grade 3, n (%) | Grade 4, n (%) |
|---|---|---|---|
| Hematological AEs | 14 (21) | 40 (60) | 11 (16) |
| Neutropenia | 19 (28) | 26 (39) | 11 (16) |
| Leukopenia | 35 (52) | 10 (15) | 1 (1) |
| Anemia | 29 (43) | 29 (43) | 0 |
| Thrombocytopenia | 8 (12) | 8 (12) | 0 |
| Lymphopenia | 10 (15) | 5 (7) | 0 |
| Febrile neutropenia | 0 | 2 (3) | 0 |
| Nonhematological AEs | 34 (51) | 12 (18) | 0 |
| Fatigue | 23 (34) | 5 (7) | 0 |
| Alopecia | 16 (24) | 0 | 0 |
| Hypertension | 8 (12) | 0 | 0 |
| Nausea/vomiting | 6 (9) | 0 | 0 |
| Peripheral sensory neuropathy | 3 (4) | 5 (7) | 0 |
| Upper respiratory infection | 3 (4) | 0 | 0 |
| Hypokalemia | 2 (3) | 1 (1) | 0 |
| Urinary tract infection | 1(1) | 1(1) | 0 |
| Dehydration | 0 | 1 (1) | 0 |
| Hyperglycemia | 0 | 1 (1) | 0 |
| Hyponatremia | 0 | 1 (1) | 0 |
| Premature menopause | 0 | 1 (1) | 0 |
| Hypophosphatemia | 4 (6) | 0 | 0 |
| Depression | 3 (4) | 0 | 0 |
| Oral mucositis | 3 (4) | 0 | 0 |
| Elevated alanine transferase | 2 (3) | 0 | 0 |
| Dyspnea | 2 (3) | 0 | 0 |
| Hypocalcemia | 2 (3) | 0 | 0 |
a
Includes events with at least two grade 2 occurrences or one grade 3 or higher. Only the highest grade per person for each category is counted.
Abbreviation: AE, adverse event.