Table 2.
Alterations in genes associated with Wnt signaling pathway
| COH/UCD | MSKCC | |||||||
|---|---|---|---|---|---|---|---|---|
| Characteristics | Total (%) (n = 341) | APC‐WT (n = 86) | APC‐MT (n = 255) | p value | Total (%) (n = 934) | APC‐WT (n = 216) | APC‐MT (n = 718) | p value |
| ARID1A | ||||||||
| Mutated | 13 (3.8) | 3 (3.5) | 10 (3.9) | 0.999 | 34 (3.6) | 3 (1.4) | 31 (4.3) | .059 |
| Nonmutated | 328 (96.2) | 83 (96.5) | 245 (96.1) | 900 (96.4) | 213 (98.6) | 687 (95.7) | ||
| CTNNB1 | ||||||||
| Mutated | 5 (1.5) | 4 (4.7) | 1 (0.4) | .015 | 11 (1.2) | 8 (3.7) | 3 (0.4) | .00063 |
| Nonmutated | 336 (98.5) | 82 (95.3) | 254 (99.6) | 923 (98.8) | 208 (96.3) | 715 (99.6) | ||
| FBXW7 | ||||||||
| Mutated | 24 (7.0) | 7 (8.1) | 17 (6.7) | .82 | 71 (7.6) | 7 (3.2) | 64 (8.9) | .005 |
| Nonmutated | 317 (93.0) | 79 (91.9) | 238 (93.3) | 863 (92.4) | 209 (96.8) | 654 (91.1) | ||
| RNF43 | ||||||||
| Mutated | 7 (2.1) | 6 (7.0) | 1 (0.4) | .0013 | 23 (2.5) | 21 (9.7) | 2 (0.3) | 3.26× 10−12 |
| Nonmutated | 334 (97.9) | 80 (93.0) | 254 (99.6) | 911 (97.5) | 195 (90.3) | 716 (99.7) | ||
| SOX9 | ||||||||
| Mutated | 27 (7.9) | 2 (2.3) | 25 (9.8) | .035 | 78 (8.4) | 10 (4.6) | 68 (9.5) | .024 |
| Nonmutated | 314 (92.1) | 84 (97.7) | 230 (90.2) | 856 (91.6) | 206 (95.4) | 650 (90.5) | ||
Abbreviations: COH, City of Hope National Medical Center; MSKCC, Memorial Sloan Kettering Cancer Center; MT, mutant; UCD, University of California, Davis; WT, wild type.