Table 4.
Multivariate survival model
| Clinicopathologic variable | COH/UCD (n = 341) | MSKCC (n = 934) | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Age at diagnosis, continuous, yr | 0.99 (0.98–1.01) | .245 | 1.00 (0.99–1.01) | .633 |
| Gender, female vs. male | 0.95 (0.71–1.27) | .735 | 0.96 (0.77–1.19) | .721 |
| Primary tumor location, right vs. left | 1.45 (1.05–2.02) | .026 | 1.16 (0.90–1.50) | .258 |
| APC, mutated vs. nonmutated | 0.62 (0.44–0.86) | .0037 | 0.63 (0.49–0.81) | 3.87× 10−04 |
| KRAS, mutated vs. nonmutated | 1.16 (0.86–1.58) | .330 | 1.72 (1.35–2.20) | 1.42× 10−05 |
| NRAS, mutated vs. nonmutated | 1.62 (0.77–3.40) | .203 | 2.70 (1.68–4.34) | 4.32× 10−05 |
| BRAF V600E, mutated vs. nonmutated | 1.73 (0.89–3.36) | .105 | 4.79 (3.10–7.39) | 1.55× 10−12 |
Abbreviations: CI, confidence interval; COH, City of Hope National Medical Center; HR, hazard ratio; MSKCC, Memorial Sloan Kettering Cancer Center, UCD, University of California, Davis.