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. 2021 Feb 18;11:623038. doi: 10.3389/fendo.2020.623038

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Copyright © 2021 Ejaz, Figaro, Woolner, Thottakam and Galley

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum melatonin levels from MEL-P in non-pregnant healthy control subjects (n = 30) compared to pregnant subjects throughout pregnancy (n = 26), *, significantly different from pregnant women in the first (P = 0.0025), second (P = 0.04), and third (P=0.0005) trimesters, Wilcoxon-Mann Whitney test. P value shown is Friedman test over the trimesters showing increasing melatonin levels (P < 0.0001). Data are shown as median, interquartile, and full range with individual raw data points overlaid.