Figure 8.

Renal apoptosis in db/m, db/db, and db/db+Fer1 groups. (A, B). Representative photographs and quantification of renal apoptosis by TUNEL assay (six sections per mouse were analyzed). (C). Representative photographs and quantification of cleaved caspase-3 in mouse kidneys measured by western blot. Male mice, n = 6/group. *P < 0.05, vs db/m group; ^# P < 0.05, vs db/db group. Db/m, db/m mice; db/db, db/db mice without Ferrostatin-1 treatment; db/db+Fer1, db/db mice with Ferrostatin-1 treatment. Data are means ± S.E.M.