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. 2021 Feb 18;12:614058. doi: 10.3389/fmicb.2021.614058

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Copyright © 2021 Yoon and Jeong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms of replicative transposition of the transposons. (A) Insertion sequence with a common region (ISCR)-mediated rolling circle replicative transposition is involved in rolling circle replication. ISCR elements lack terminal inverted repeats, and a single copy of the element is able to transpose adjacent DNA sequences (Toleman et al., 2006). (B) A Tn3-mediated copy-and-paste replicative transposition requires both a transposase and a resolvase. The transposon is replicated, joining the donor and the recipient in a cointegrate, which is resolved to give the donor and the recipient of the transposon (Grindley, 1983).