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. 2021 Feb 18;12:630389. doi: 10.3389/fimmu.2021.630389

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Copyright © 2021 Ortutay, Grönholm, Laitinen, Keresztes-Andrei, Hermelo and Pesu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FURIN SE regulated RNA expressions in activated EL-4 T cells clones. “Empty” and SE EL-4 T cell clones were stimulated for 6 h with PMA and ionomycin (n = 3/genotype). Gene expression of clones was analyzed using RNA sequencing. (A) Heatmap representation of significantly differentially expressed genes (p adj < 0.05). Genes are arranged according to the expression pattern similarity, colors representing the log2-transformed internally normalized RNA read counts. (B) Differentially expressed genes are categorized into groups based on common features, such as close genomic location, validated or predicted (*) FURIN cleavage, or tie to IFNγ.