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LTB4 and LTC4 promote HSC activation via ERK signaling pathway. (A,B) The protein levels of p-ERK, t-ERK and β-tubulin in HSC after treatment with LTB4, LTC4 or TGF-β1 for 30 min (C,D) Western blot analysis of protein levels of α-SMA and Col1a1 in primary HSC isolated from 5-LO−/− mice and pre-treated with PD98059 before administration of LTB4 or LTC4. Data are mean ± SEM, n = 5, *p < 0.05, **p < 0.01.
