Skip to main content
. 2021 Feb 18;12:633353. doi: 10.3389/fphar.2021.633353

FIGURE 1.

FIGURE 1

circMAP3K11 is overexpressed in periodontitis tissue and exert suppressing effect on regenerative capacity of PDLSCs (A) The expression level of circMAP3K11 in periodontitis and normal samples by RT-PCR (B) The expression level of circMAP3K11 in PDLSCs transfected with circMAP3K11 overexpression plasmid, siRNA targeted circMAP3K11, and corresponding control (mock and si-NC) (C) The cell viability of PDLSCs transfected with circMAP3K11 overexpression plasmid, siRNA targeted circMAP3K11, and corresponding control was determined by the MTT assay (D) The proliferation of PDLSCs transfected with circMAP3K11 overexpression plasmid, siRNA targeted circMAP3K11, and corresponding control was investigated by colony formation (E) The FCM was performed to detect the cell apoptosis of PDLSCs transfected with circMAP3K11 overexpression plasmid, siRNA targeted circMAP3K11, and corresponding control (F) Cell migration ability of PDLSCs transfected with transfected with circMAP3K11 overexpression plasmid, siRNA targeted circMAP3K11, and corresponding control was evaluated by transwell assay (G) Western blot showed the protein expression levels of Runx2, OSX, ATF4, and BSP in PDLSCs transfected with transfected with circMAP3K11 overexpression plasmid, siRNA targeted circMAP3K11, and corresponding control. Note: *p < 0.05, **p < 0.01, and ***p < 0.005.