TABLE 1.

Constituents of the formulation showing the parameters investigated to obtain the optimized formulation.

Formulation code	Lactide to glycolide ratio	Inherent viscosity (dL/g)	Organic solvent	Drug to polymer ratio	PVA surfactant concentration
Lactide:glycolide
A1a	50:50	0.55–0.75	Chloroform	1:6	2.5
A2	65:35	0.75	Chloroform	1:6	2.5
A3	75:25	0.55–0.75	Chloroform	1:6	2.5
A4	85:15	0.64	Chloroform	1:6	2.5
A5	100:0	0.55–0.75	Chloroform	1:6	2.5
Organic solvent
B1a	50:50	0.55–0.75	Chloroform	1:6	2.5
B2	50:50	0.55–0.75	Dichloromethane	1:6	2.5
B3b	50:50	0.55–0.75	Ethyl acetate	1:6	2.5
B4	50:50	0.55–0.75	Acetone	1:6	2.5
Inherent viscosity
C1	50:50	0.26–0.54	Ethyl acetate	1:6	2.5
C2b	50:50	0.55–0.75	Ethyl acetate	1:6	2.5
C3	50:50	0.76–0.94	Ethyl acetate	1:6	2.5
C4	50:50	0.95–1.20	Ethyl acetate	1:6	2.5
Drug:Polymer
D1	50:50	0.55–0.75	Ethyl acetate	1:20	2.5
D2	50:50	0.55–0.75	Ethyl acetate	1: 12	2.5
D3c	50:50	0.55–0.75	Ethyl acetate	1:8.5	2.5
D4b	50:50	0.55–0.75	Ethyl acetate	1:6	2.5
D5	50:50	0.55–0.75	Ethyl acetate	1:4	2.5
Surfactant concentration
E1	50:50	0.55–0.75	Ethyl acetate	1:8.5	1
E2	50:50	0.55–0.75	Ethyl acetate	1:8.5	2
E3c	50:50	0.55–0.75	Ethyl acetate	1:8.5	2.5
E4	50:50	0.55–0.75	Ethyl acetate	1:8.5	3
E5	50:50	0.55–0.75	Ethyl acetate	1:8.5	4
F*	85:15	0.64	Ethyl acetate	1:8.5	2

a, b, and c, same formulation variables; F*, optimized formulation.