TABLE 2.

Physicochemical properties and drug loading of andrographolide formulation with different lactide to glycolide ratio.

Formulation code	Particle size (nm)	Polydispersity index (PI)	Zeta potential (mV)	Drug loading (%)	Encapsulation efficiency (%)
A1	2093	0.200.01	−23.53.8	1.50.4	11.52.9
A2	1977	0.140.03*	−14.40.1*	1.00.2	7.51.5
A3	2003	0.090.01***	−13.52.5*	1.10.3	9.12.8
A4	1942*	0.100.01***	−17.25.6	1.30.2	9.81.7
A5	2026	0.080.02***	−16.21.8	1.20.1	8.71.0

Results are expressed as mean ± SD (n = 3). *signifies p < 0.05, ***signifies p < 0.001 significant differences with respect to A1. A1, 50:50 PLGA; A2, 65:35 PLGA; A3, 75:25 PLGA; A4, 85:15 PLGA; A5, 100 PLA.