TABLE 3.

Physicochemical properties and drug loading of andrographolide nanoformulation with different solvent.

Formulation code	Particle size (nm)	Polydispersity index (PI)	Zeta potential (mV)	Drug loading (%)	Encapsulation efficiency (%)
B1	2093	0.200.01	−23.53.8	1.50.4	11.52.9
B2	2407***	0.130.07	−17.33.5	1.70.3	12.82.0
B3	1126***	0.200.02	−11.40.9*	2.30.3	18.22.1
B4	2198	0.100.01*	−10.64.7*	2.30.8	17.86.2

Results are expressed as mean ± SD (n = 3). *signifies p < 0.05, ***signifies p < 0.001 significant differences with respect to B1 formulation. B1, chloroform; B2, dichloromethane; B3, ethyl acetate; B4, acetone.