TABLE 4.

Physicochemical properties and drug loading of andrographolide formulation of different PLGA molecular weights.

Formulation code	Particle size (nm)	Polydispersity index–PI	Zeta potential (mV)	Drug loading (%)	Encapsulation efficiency (%)
C1	1073	0.200.03	−10.40.9	1.20.1***	9.00.6***
C2	1126	0.200.02	−11.40.9	2.30.3	18.22.1
C3	1394***	0.100.05*	−8.10.8*	1.10.2***	8.41.4***
C4	1436***	0.120.04	−10.30.1	1.50.1**	11.60.9**

Results are expressed as mean ± SD (n = 3). *signifies p < 0.05, **signifies p < 0.01, ***signifies p < 0.001 significant differences with respect to C2 formulation. C1, 6.7–31.3 kDa; C2, 31.3–57.6 kDa; C3, 57.6–91.6 kDa; C4, 91.6–111.5 kDa.