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. 2020 Apr 7;11(1):15–27. doi: 10.1016/j.jpha.2020.03.012

Table 2.

Fluorescent probe substrates for COMT.

Substrates Chemical structures Metabolic sites Enzyme sources Km (μM) Vmax (nmol/min/mg) λex./em. (nm) Refs.
DHMC Image 29 8-OH S-COMT 5.17 ± 0.28 123.30 ± 2.09 320/510 [84]
3-BTD Image 30 8-OH S-COMT 0.79 ± 0.07 44.50 ± 1.200 390/520 [85]

DHMC: 7,8-Dihydroxy-4-methylcoumarin; 3-BTD: 3-(Benzo [d]thiazol-2-yl)-7,8-dihydroxy-2H-chromen-2-one.