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. 2020 Apr 7;11(1):15–27. doi: 10.1016/j.jpha.2020.03.012

Table 3.

Three marketed COMT inhibitors.

Names Groups Chemical structures Side effects Refs.
Tolcapone Approved,
Withdrawn		 Image 31 Liver toxicity [28]
Entacapone Approved, Investigational Image 32 Severe diarrhea [29]
Opicapone Approved, Investigational Image 33 Unknown [30]