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. 2021 Feb 18;12:620741. doi: 10.3389/fphar.2021.620741

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Copyright © 2021 Hu and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of SIRT3 activity and the AMPK signaling pathway decreased HEI-OC1 cell viability with icariin pretreatment. (A) To determine the role of SIRT3 and AMPK in the protective effect of icariin on gentamicin-damaged HEI-OC1 cells, cells were pretreated with 50 μM 3-TYP (SIRT3 inhibitor) and 10 μM compound C (AMPK inhibitor) for 2 h. Cell viability in the inhibitor group was significantly lower compared with that in the non-inhibitor group. In addition, cell viability was not significantly affected by single inhibitor treatment. (B) Measurement of cell viability in (A). Each experiment was performed three times. Ns, not significant; N = 8 in each group; *p < 0.05; ***p < 0.001; one-way analysis of variance and Tukey’s multiple comparison test.