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. 2021 Feb 18;9:607121. doi: 10.3389/fcell.2021.607121

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Copyright © 2021 Schneider, De Cegli, Nagarajan, Kretschmer, Matthiessen, Intartaglia, Hotaling, Ueffing, Boldt, Conte and May-Simera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Loss of Bbs8 induces a switch in RPE-specific gene expression from P11 to P29. (A) Venn diagram showing differentially expressed genes (DEGs) obtained via transcriptomic analysis. The number of specific and common DEGs and the orientation of expression are shown. DW, down-regulated; UP, up-regulated. (B) Pie charts depicting % up- or down-regulated genes for three different categories; fetal RPE-specific genes, adult RPE-specific genes and RPE signature genes. At P11 all categories have an increased down-regulation. At P29 fetal RPE-specific genes and RPE signature genes become up-regulated.