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. 2021 Feb 18;9:607121. doi: 10.3389/fcell.2021.607121

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Copyright © 2021 Schneider, De Cegli, Nagarajan, Kretschmer, Matthiessen, Intartaglia, Hotaling, Ueffing, Boldt, Conte and May-Simera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GOEA of commonly regulated DEGs from Bbs8^−/− RPE at P11 and P29. (A) We identified three clusters of Biological processes (BP) that were significantly up-regulated and three that were significantly down-regulated at both time points. Terms are ranked according to the Enrichment score of each BP cluster. Light bright green bar denotes photoreceptor-specific genes. DW, down-regulated; UP, up-regulated. (B) Heatmap of differentially regulated genes associated with processes in A.