Figure 6.

Pseudoglandular, canalicular, and saccular phase of lung development (a‐c). Exemplary micro‐CT images of coronary cross sections at ED15 (a), ED20 (b), and N0 (c). Additional histological sections (H&E) of corresponding pulmonary tissue (×10 magnification; d,e,f)[...] (a,d)[...](b,e)[...](c,f)). Images were adjusted for best visualization. In the pseudoglandular stage, lung parenchyma had a glandular structure and terminal buds grew out into the surrounding mesenchyme (a). In the later stages, branching and penetration of the epithelial tubules into the surrounding tissue were observed. During the canalicular stage the airways expanded (b). In the saccular stage, transition from branching of the airways to alveolarization could be observed (c). Scalebar 1 mm