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. Author manuscript; available in PMC: 2021 Mar 4.
Published in final edited form as: Nat Genet. 2020 Apr 27;52(5):482–493. doi: 10.1038/s41588-020-0610-9

Figure 4:

Figure 4:

Human replication of cell type – trait associations. Cell type - trait associations for 15 cell types (derived from single-nuclei RNA-seq) from 2 different brain regions (cortex, hippocampus). (A) Cell type - trait associations for 31 cell types (derived from single-nuclei RNA-seq) from 3 different brain regions (frontal cortex, visual cortex and cerebellum). (B) The mean strength of association (−log10P) of MAGMA and LDSC is shown and the bar color indicates whether the cell type is significantly associated with both methods, one method or none (significance threshold: 5% false discovery rate). INT (intelligence), SCZ (schizophrenia), EDU (educational attainment), NEU (neuroticism), BMI (body mass index), BIP (bipolar disorder), MDD (Major depressive disorder), MEN (age at menarche), ASD (autism spectrum disorder), MIG (migraine), PAR (Parkinson’s disease), ADHD (attention deficit hyperactivity disorder), ICV (intracranial volume), HIP (hippocampal volume), AN (anorexia nervosa), ALZ (Alzheimer’s disease), ALS (amyotrophic lateral sclerosis), STR (stroke).