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. 2021 Feb 18;12:615802. doi: 10.3389/fneur.2021.615802

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Copyright © 2021 Brennan, Garcia-Curran, Patterson, Luo and Baram.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Seizure-like activity reduces total miR-124 levels but promotes miR-124 packaging into ECVs and release. (A) qPCR analysis reveals rapid reduction of miR-124 levels in organotypic hippocampal slices following seizure-like events. (B) miR-124 levels in culture media increase following seizure-like events. (C) Analysis of miR-124 levels from exosomes isolated from culture media shows enrichment of miR-124 in exosomes following seizure-like events. *p < 0.05.