Table 1.
Receptor binding profiles of antipsychotic agents.
| Receptor | LUR | APZ | CLZ | PMZ | QTP | RIS | ZTP | BNS | VTX |
|---|---|---|---|---|---|---|---|---|---|
| 5-HT1AR | 6.8 | 5.6 | 124 | 650 | 432 | 423 | 471 | 804 | 15.0 |
| 5-HT2AR | 2.0 | 8.7 | 5.4 | 48.4 | 100 | 0.2 | 2.7 | 0.8 | |
| 5-HT3R | >1,000 | 630 | 241 | >1,000 | >1,000 | >1,000 | 472 | >1,000 | 3.7 |
| 5-HT7R | 0.5 | 10.3 | 18.0 | 0.5 | 307 | 6.6 | 12.0 | 183 | 19.0 |
| α2A | >1,000 | 74.3 | 37.0 | >1,000 | >1,000 | 16.5 | 180 | (530) | |
| α2B | >1,000 | 102 | 26.5 | 821 | 90.0 | 108 | 5.4 | ||
| α2C | 10.8 | 37.9 | 6.0 | 377 | 28.7 | 1.3 | 106 | ||
| D1R | 262 | >1,000 | 266 | >1,000 | 712 | 244 | 71.0 | >1,000 | |
| D2R | 1.7 | 3.3 | 157 | 0.3 | 245 | 3.6 | 25.0 | 0.1 | |
| References | (26) | (27, 28) | (29, 30) | (31) | (32) | (28, 33) | (34) | (35) | (36) |
lurasidone (LUR), aripiprazole (APZ), clozapine (CLZ), pimozide (PMZ), risperidone (RIS), zotepine (ZTP), and blonanserin (BNS), and antidepressant vortioxetine (VTX) against serotonin (5-HT) type 1A (5-HT1AR), type 2A (5-HT2AR), type 3 (5-HT3R), and type 7 (5-HT7R) receptor, and dopamine receptors type 1 (D1R) and 2 (D2R). Data are equilibrium constant (Ki) values (nM).