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. 2021 Feb 18;12:613067. doi: 10.3389/fmicb.2021.613067

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Copyright © 2021 Saha and Kundu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic representation of inter and intramodular interactions. Intermodular interactions are defined as the interactions between two proteins A and B if they participate in distinct functional complexes without having any shared protein complex between A and B (DI = 0). Intramodular interactions are defined as the interactions between protein A and B when there is at least one functional protein complex shared between A and B (DI = 1). (B) Boxplot showing a significant difference in the distribution of DI between targeted PPI and non-targeted PPI. DI is defined as the ratio of the number of shared protein complexes between two targeted and non-targeted interacting protein pairs to the total number of unique protein complexes in which A and B participate. (C) Stacked bar plot showing a higher percentage of intermodular interactions among targeted PPIs as compared to non-targeted PPIs.