Table 1.

ADAMTS and diseases or conditions that proceed with an inflammatory component.

ADAMTS	Disease/condition	Pro-/Anti-inflammatory	Mouse modela	Cell typeb	Substratec
ADAMTS1	Aortic aneurysm and dissections [40,41,43,44]	Pro/Anti	Inducible whole-body knockout [43], Constitutive whole-body heterozygous [44]		Versican [40,41]
	Atherosclerosis [31,35,36]	Pro/Anti		THP-1, macrophages [30,31]	Versican [35]
	LPS-induced inflammation [7,25]	Pro
	Regulation of immune populations [21]	n.d.	Constitutive whole-body knockout [21]		Versican [21]
ADAMTS2	Dermatitis and skin dysfunction [[51], [52], [53]]	Anti	Constitutive whole-body knockout [52]	Monocytes, macrophages [53]
ADAMTS4	Aortic aneurysm and dissections [40,42]	Pro	Constitutive whole-body knockout [42]		Versican [40,42]
	Atherosclerosis [[30], [31], [32],34]	Pro	Constitutive whole-body knockout [34]	THP-1, macrophages [30,31]	Versican [32,34]
	Ischemic stroke and CNS disorders [45]	Anti
	Osteoarthritis [54]	Pro			Aggrecan [54]
ADAMTS5	Atherosclerosis [30,31]	n.d.		THP-1, macrophages [30,31]
	Influenza virus infection [60]	Pro	Constitutive whole-body knockout [60]		Versican [60]
	Osteoarthritis [[54], [55], [56], [57]]	Pro			Aggrecan [57]
ADAMTS7	Atherosclerosis [30,33,37,38]	Pro	Constitutive whole-body knockout [38]	THP-1, Macrophages [30,33]
ADAMTS8	Atherosclerosis [30]	Pro		THP-1 [30]
ADAMTS9	Atherosclerosis [30]	Pro		THP-1 [30]
ADAMTS12	Asthma or allergy [27]	Anti	Constitutive whole-body knockout [27]
	Inflammatory response [26]	Anti	Constitutive whole-body knockout [26]
	Osteoarthritis and rheumatoid arthritis [58,59]	Pro			COMP [58]
ADAMTS13	Autoimmune encephalomyelitis [62]	Anti
	Multiple sclerosis [61]	Anti
	Thrombotic thrombocytopenic purpura [47,50]	Anti			Von Willebrand Factor [47]
	Traumatic microvascular injury [48]	n.d.	Constitutive whole-body knockout [49]		Von Willebrand Factor [48]
ADAMTS14	Skin dysfunction [52]	Anti	Constitutive whole-body knockout [52]

n.d.: not determined.

^aMouse models used to study the referred ADAMTS protease in a specific disease or condition.

^bImmune cell type expressing the referred ADAMTS protease.

^cSubstrate contributing to the mentioned pro/anti-inflammatory role.