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. 2021 Feb 24;23(4):300. doi: 10.3892/mmr.2021.11939

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Copyright: © Wu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — miR-491 inhibits CRC cell proliferation. (A) miR-491 expression in the different colorectal cancer cell lines (HCT116, SW480, HT29, LoVo and SW620) and normal colon cell line (FHC). *P<0.05 vs. FHC. (B) Expression of miR-491 was increased after transfection of miR-491 mimic both in LoVo and SW620 cells. miR-491 inhibited (C) SW620 and (D) LoVo cell proliferation, based on the Cell Counting Kit-8 assays. (E) miR-491 suppressed SW620 and LoVo cell colony formation ability. Right panel, representative figures; left panel, quantitative analysis. *P<0.05, **P<0.01 vs. NC. Experiments were repeated three times. miR, microRNA; CCK-8, Cell Counting Kit-8; NC, negative control; OD, optical density; NS, not significant.