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Hypothesized biologic mechanisms linking physical activity, excess body fat, and sedentary behavior to cancer risk. IGF‐1, insulin‐like growth factor‐1; IGFBP‐3, insulin growth factor‐binding protein‐3; IL‐6, interleukin‐6; TNF‐α, tumor necrosis factor‐α; IL‐1β, interleukin‐1β; CRP, C‐reactive protein; SAA, serum amyloid A; SHBG, sex hormone‐binding globulin.
