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. Author manuscript; available in PMC: 2021 Mar 4.
Published in final edited form as: J Environ Sci Health C Toxicol Carcinog. 2021;39(1):68–86. doi: 10.1080/26896583.2021.1880242

Figure 4.

Figure 4.

The robustness of CYP3A4-overexpressing cells with different passages in response to the toxicity of amiodarone and dronedarone. Empty vector-transduced or CYP3A4-overexpressing HepG2 cells at passage number 2 and 10 were treated with the indicated concentrations of amiodarone (A and B) or dronedarone (C and D) for 24 h. Cytotoxicity was measured using LDH assays. The results shown are mean ± S.D. from three independent experiments.*, p < 0.05 compared with that of empty vector control.