Table 1. Potential Biomarker Identificationa.
no | RT (min) | mass-to-charge ratio | type | sample | identified compound | trend |
|
---|---|---|---|---|---|---|---|
group II versus group I | group III versus group II | ||||||
1 | 1.87 | 338.0814 | M + H | urine | 3-indole carboxylic acid glucuronide | ↑** | ↓ |
2 | 3.34 | 237.0826 | M – H | urine | cystathionine sulfoxide | ↑** | ↓ |
3 | 3.43 | 323.0629 | M – H | serum | uridine 5′-monophosphate | ↓** | ↑## |
4 | 3.44 | 159.1062 | M – H | urine | oxoadipic acid | ↑** | ↓## |
5 | 4.06 | 217.0212 | M – H | urine | 3-hydroxysebacic acid | ↓* | |
6 | 4.20 | 273.1535 | M + H | urine | estradiol | ↓** | ↑ |
7 | 4.25 | 191.1064 | M – H | urine | citric acid | ↑** | ↓## |
8 | 4.70 | 307.0663 | M + Na | serum | xanthosine | ↑** | ↓ |
9 | 4.82 | 369.2309 | M – H | serum | 3-oxo-4,6-choladienoic acid | ↓** | |
10 | 5.57 | 209.1193 | M + H | urine | l-kynurenine | ↓** | ↑## |
11 | 5.70 | 243.1032 | M + H | urine | thymidine | ↑** | ↓## |
12 | 6.21 | 407.2895 | M – H | serum | cholic acid | ↑* | ↓# |
13 | 9.11 | 317.2158 | M – H | serum | leukotriene A4 | ↓** | |
14 | 11.56 | 594.3764 | M + FA – H | serum | lysoPC (20:1(11Z)) | ↓** | ↑# |
15 | 13.57 | 308.0930 | M + H | urine | glutathione | ↑** | ↓## |
Compared to group I: *P < 0.05 and **P < 0.01; compared to group II: #P < 0.05 and ##P < 0.01.