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. 2021 Feb 15;6(8):5075–5090. doi: 10.1021/acsomega.0c05276

Figure 5.

Figure 5

(i) TEM and DLS characterization of Dox-NGs (a) and Dox-iRGD-BSA-AuNCs-NGs (b). Dox-iRGD-BSA AuNCs NGs. (ii) The in vitro release profiles of Dox from various Dox-loaded NGs at 37 °C in PBS of different pH. (iii) The cellular uptake of different Dox formulations in HUVECs (c) and B16 (d) cells after 1, 4, and 12 h incubation. (iv) The intracellular delivery of BSA-AuNCs-NGs (A and C) and iRGD-BSA-AuNCs-NGs (B and D) in HUVECs (A and B) and B16 cells (C and D). The cells were incubated with BSA-AuNCs-NGs and iRGD-BSA AuNCs-NGs at 250 μg/mL for 4 h at 37 °C and then detected by confocal microscopy. Reprinted with permission from ref (10). Copyright 2013 Elsevier.