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. 2021 Feb 15;6(8):5075–5090. doi: 10.1021/acsomega.0c05276

Figure 7.

Figure 7

(i) Photothermal activity and thermoresponsiveness of the semi-interpenetrated PPY nanogels. (a) IR pictures of a sample during irradiation and (b) concentration-dependent temperature difference reached after 5 min of NIR irradiation. (ii) Release profiles of MTX above and below VPTT of semi-interpenetrated PPY nanogels upon NIR irradiation. (iii) Photothermal and combinational therapy in vitro. Cell viability of A549 lung carcinoma cell line determined by an MTT assay incubated for 48 h with MTX-loaded (10 wt %) and -unloaded PPY nanogels with and without exposure to NIR laser (785 nm, 500 mW) for 7 min. (iv) (a) x–y MIPs of PA images of excised organs at 800 nm. (b) Mean PA image intensity of excised, formalin-fixed organs of a female nude mouse treated over five consecutive days with 100 mg/kg of PPY nanogels. (c) Photothermal response (max. ΔT after 5 min) of the same samples after irradiation with the output of a NIR lamp. (v) (A) IR image of mice under NIR irradiation with i.t. injected nanogels. (B) MIP of photoacoustic image (PI) of an untreated control. (C) MIP of PI of a tumor after injection of nanogels and 5 min NIR irradiation ex vivo. (D, E) Rel. tumor growth over time of mice treated i.t. with MTX-loaded various nanogels with and without exposure to NIR. (F) Rel. tumor growth over time after i.v. administration of five consecutive doses of PPY/Co-dPG and exposure to NIR (5 min) 48 h after the last injection with respect to controls. Reprinted with permission from ref (18). Copyright 2019 Elsevier.