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. 2021 Feb 15;6(8):5075–5090. doi: 10.1021/acsomega.0c05276

Table 1. Representative “Smart” Biocompatible Nanogel Systems and Their Synthesis Routes, Types of Experiments, Various Therapeutics, and Potential Therapeutic and Diagonostic Applications.

nanogel system synthesis method therapeutics/theranostic agent type of experiment (in vitro/in vivo) application ref
PNIPAM NGs precipitation-free radical polymerization Dox in vitro (HeLa cells) drug delivery (4)
P(NIPAM-co-AA) NGs free radical precipitation polymerization Dox in vitro (HUVECs and B16 cells) drug delivery (10)
(PAA-co-PSPMA) NGs emulsion radical polymerization Dox in vitro (MCF-7 cells) drug delivery and cell imaging (17)
P(NIPAM- PPY) NGs free radical polymerization MTX in vitro (A549 cells) photothermal chemotherapy (18)
in vivo (A549 xenograft tumor bearing mice model)
PNIPAM-co-NCPAM NGs RAFT polymerization protein in vitro (RAW 264.7 cells) protein delivery (23)
cationic glyco-NGs RAFT polymerization siRNA in vitro (HeLa cells) gene delivery (11)
p(DEAEMA-co-tBMA) NGs ATRP siRNA in vitro (RAW 264.7 cells) gene delivery (12)
PEI NGs miniemulsion polymerization Fe3O4 NPs/Dox in vitro (4T1 cells) MR image-guided chemotherapy (29)
in vivo (xenografted 4T1 breast tumor model)
zwitterionic NGs precipitation-free radical polymerization indocyanine green (ICG)/Dox in vitro (HepG2 cells) photothermal therapy (15)
in vivo (H22-bearing mice)
PNVCL/Fe3O4 NGs miniemulsion polymerization 5-fluorouracil in vitro (SW620 cells) magnetic guiding drug delivery (30)
dextran NGs emulsion polymerization Dox in vitro (MDA-MB-231 cells) drug delivery (31)
in vivo (MDA-MB-231 cells mice)
poly(carboxybetaine methacrylate) NGs emulsion polymerization ESIONPs in vitro (U87-MG cells) MR imaging (32)
in vivo (tumor-bearing mice)
Ag@p[(VPBA-DMAEA)] NGs free radical polymerization insulin in vitro (Cos7 cells) glucose-sensing and insulin delivery (35)
polypeptide NGs NCA ring-opening polymerization Dox in vitro (A549 cells) image-guided drug delivery (13)
in vivo (tumor-bearing nude mice)
supramolecular NGs free radical polymerization Dox/Zn-Por in vitro (HepG2 and HeLa cells) chemo-photodynamic therapy (19)
in vivo (B16F10-heterografted melanoma model)