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. 2021 Feb 19;11(3):890–897. doi: 10.1002/2211-5463.13109

Fig. 3.

Fig. 3

Pin1 strikingly reverses JNK1‐repressed activity of TAp63γ and makes it hyperactive. (A) Saos‐2 cells were transfected with a mixture of Bax‐Luc and TK‐Renilla plus indicated plasmids. Bax‐Luc expression levels were measured and presented as mentioned above (n = 3), while IB analyses were performed to detect indicated proteins. Two‐tailed t‐test was used for comparison between two groups; **P < 0.01. (B) Saos‐2 cells transfected with indicated plasmids were subjected to cell survival measurement with MTT. Cell viabilities were presented as mentioned above (n = 3). Two‐tailed t‐test was used for comparison between two groups; **P < 0.01. (C) Saos‐2 cells were transfected with a mixture of Bax‐Luc and TK‐Renilla plus indicated plasmids or siRNAs. Bax‐Luc expression levels were measured and presented as mentioned above, while IB analyses were performed to detect indicated proteins. Two‐tailed t‐test was used for comparison between two groups; **P < 0.01; NS, nonsignificant. The error bars (A–C) indicate SD (n = 3).