Fig. 4.

Toxicity study of c4D10 in vivo. B‐hSIRPα/hCD47 mice (n = 3) were treated with 10 mg·kg⁻¹ anti‐CD47 antibodies or control through an intravenous route on days 0, 2 and 4, routine blood tests were performed (A), blood chemistry levels were tested on day 6 (B) and mouse weights were recorded (C). ALT, alanine amino‐transferase; AST, aspartate transaminase; CHOL, cholesterol; CR, creatinine; GLU, glucose; TRIG, triglyceride; UREA, urea. All error bars indicate the SEM (n = 3). *P < 0.05. Statistics were performed using one‐way analysis of variance (Tukey–Kramer).