Table 2.
The top 20 TFs of hub genes in key modules. NES, normalised enrichment score.
| Hub genes source | TFs | NES | Targets | Motifs/Tracks |
|---|---|---|---|---|
| Brown module | E2F4 | 10.219 | 4 | 7 |
| SIN3A | 8.997 | 4 | 7 | |
| CRX | 7.359 | 2 | 17 | |
| PAX4 | 6.075 | 3 | 8 | |
| SOX14 | 5.985 | 3 | 3 | |
| ZFY | 5.955 | 3 | 6 | |
| ALX4 | 5.107 | 2 | 5 | |
| FOXM1 | 5.032 | 3 | 4 | |
| FOXJ2 | 4.927 | 2 | 9 | |
| GTF3C2 | 4.672 | 1 | 7 | |
| KLF5 | 4.619 | 2 | 15 | |
| ZBED1 | 4.619 | 2 | 3 | |
| ZNF423 | 4.589 | 1 | 1 | |
| RXRA | 4.574 | 2 | 10 | |
| ARID3C | 4.567 | 2 | 6 | |
| ARID3A | 4.544 | 1 | 1 | |
| YY1 | 4.529 | 1 | 15 | |
| NF1 | 4.522 | 1 | 3 | |
| E2F3 | 4.507 | 1 | 3 | |
| E1V4 | 4.499 | 1 | 3 | |
| Turquoise module | ATF2 | 6.734 | 4 | 44 |
| REST | 6.460 | 3 | 11 | |
| ESR1 | 5.375 | 4 | 4 | |
| EBF1 | 4.895 | 3 | 4 | |
| CREB1 | 4.885 | 3 | 5 | |
| HOXB4 | 4.838 | 3 | 3 | |
| OSR1 | 4.806 | 2 | 3 | |
| TEAD4 | 4.668 | 2 | 1 | |
| CLK1 | 4.574 | 2 | 1 | |
| RFX2 | 4.369 | 2 | 30 | |
| GCM1 | 4.058 | 3 | 4 | |
| HOXA5 | 3.990 | 3 | 25 | |
| PRRX1 | 3.916 | 2 | 4 | |
| DBP | 3.911 | 2 | 2 | |
| ZBTB18 | 3.742 | 2 | 2 | |
| NFKB1 | 3.516 | 2 | 1 | |
| FOXN4 | 3.155 | 1 | 6 | |
| CRX | 3.110 | 1 | 1 | |
| GATA5 | 3.089 | 1 | 4 | |
| TEAD1 | 3.073 | 3 | 4 |