Table 2.

Agreement between patients and clinicians -- maximum symptom “severity” and ‘interference” scores at any time during treatment (percent) (N=267)

Agreement on maximum symptom “severity” score
Symptom	Agree “low”	Agree “high”	Clinician “high”, patient “low”	Patient “high”, clinician “low”	Kappa*
Constipation	65	11	3	21	.329
Diarrhea	62	14	4	21	.378
Nausea	65	14	7	14	.437
Vomiting	90	2	4	5	.220
Mucositis oral	74	10	5	12	.447
Fatigue, lack of energy	31	48	7	14	.570
Aching joints/arthralgia	60	17	5	18	.455
Aching muscles/myalgia	62	13	6	20	.363
Peripheral neuropathy	60	16	11	13	.413
Anxiety	57	16	5	22	.372
Feeling sad, unhappy/depression	73	10	2	15	.444
Insomnia	43	27	5	25	.416
Dyspnea/light-headedness	77	4	4	15	.224
Abdominal pain	83	2	2	14	.188
Edema limbs	79	4	1	17	.245
General pain	60	20	8	12	.523
Hot flashes	66	16	8	11	.513
Agreement on maximum symptom “interference” score
Symptom	Agree “low”	Agree “high”	Clinician “high, patient “low”	Patient “high”, clinician “low”	Kappa*
Constipation	77	6	7	9	.337
Diarrhea	70	11	6	13	.426
Nausea	68	11	9	12	.384
Vomiting	89	1	4	6	.150
Mucositis oral	80	6	9	6	.348
Fatigue, lack of energy	32	44	11	13	.522
Aching joints/arthralgia	64	14	9	14	.402
Aching muscles/myalgia	68	12	7	14	.406
Peripheral neuropathy	64	10	18	8	.256
Anxiety	68	13	9	11	.441
Feeling sad, unhappy/depression	79	8	4	9	.506
Insomnia	52	21	12	16	.398
Dyspnea/light-headedness	78	4	4	12	.275
Abdominal pain	85	3	1	11	.265
Edema limbs	86	2	2	10	.247
General pain	61	18	11	10	.466
Hot flashes	71	8	16	5	.311

“Low” = patient-reported none or mild; clinician rated toxicity grade 0 or 1

“High” = patient-reported moderate, severe or very severe; clinician-rated toxicity grade 2, 3 or 4

Kappa interpretation: < 0.0 less than chance agreement, 0.01 – 0.20 slight agreement, 0.21 – 0.40 fair agreement, 0.41 – 0.60 moderate agreement, 0.61 – 0.80 substantial agreement, and 0.81 – 0.99 almost perfect agreement.

^*All kappas were statistically significant (p=<.05)