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. 2020 Dec 16;8:566932. doi: 10.3389/fcell.2020.566932

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Copyright © 2020 Yan, Xuan, Gao, Shen, Cao, Hong, Chen, Cui, Ye, Fang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CCMAlnc is upregulated in CRC and associated with poor prognosis. (A) Statistical analysis of CCMAlnc expression in CRC and the paired adjacent normal tissues of the Renji cohort (n = 53). (B) The expression of CCMAlnc in CRC and normal tissues in the TCGA database. (C) Survival was analyzed and compared between patients with high and low CCMAlnc expression in the TCGA database. (D) Schematic representation of the mechanism of the CCMAlnc/miR-5001-5p axis as a switch that regulates human CRC progression by stabilizing the expression of HES6.