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. 2021 Mar 4;21:149. doi: 10.1186/s12935-021-01825-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Exosomal LINC00470 promoted the proliferation of glioma cells through regulating autophagy. Note: U251 and SWO-38 cells were incubated with GBM-exo or transfected with pcDNA3.1-LINC00470 or treated with Rapa. MDC staining was used to detect acidic autophagosomes (a). Detection of the expression of autophagy-related proteins, LC3-I, Beclin1 and p62 was conducted by Western blotting (b). Proliferation was examined through CCK8 and clone formation assay (c–d). FCM examined the effect of LINC00470 and autophagy on cell cycle of glioma cells (e). * P < 0.05, ** P < 0.01, *** P < 0.001, compared to Control group. # P < 0.05, ## P < 0.01, compared to pcDNA3.1-LINC00470 group. GBM-exo, exosomes derived from patients with glioma; MDC, monodansylcadaverin staining; FCM, Flow cytometry