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. 2021 Feb 17;6(8):5490–5498. doi: 10.1021/acsomega.0c05817

Figure 4.

Figure 4

Levels of CAR and its metabolites in the liver depend on both maternal and embryonic genotypes. The levels of CAR and metabolites were determined in the livers of P0 pups. The data are presented taking into account both maternal and embryonic Dhcr7 genotypes. A two-way ANOVA analysis is presented in Table 2. Each symbol corresponds to a single pup. Bars correspond to the mean ± SEM; statistical significance: **p < 0.01; ****p < 0.0001. Note that for CAR, DCAR, and DDCAR, there is a summation effect between the maternal and pup Dhcr7 genotype, with the Dhcr7+/– pups born to Dhcr7+/– mothers showing the lowest levels.