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. 2021 Feb 17;6(8):5490–5498. doi: 10.1021/acsomega.0c05817

Figure 6.

Figure 6

Dhcr7+/– mice metabolize ARI and CAR faster than WT mice. ARI (A) and CAR turnovers (B) were calculated by determining the ratio of drug metabolites over the parent drug. WT and Dhcr7+/– pups are depicted in green and red, respectively. Opened symbols denote pups from WT mothers and filled symbols denote pups from Dhcr7+/– mothers. Bars correspond to the mean ± SEM; statistical significance: **p < 0.01; ***p < 0.0001. Note that the parent drug/metabolite ratio was increased in Dhcr7+/– pups across all tissues.