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. 2021 Feb 17;6(8):5490–5498. doi: 10.1021/acsomega.0c05817

Figure 8.

Figure 8

Human fibroblasts with a DHCR7+/– genotype have lower drug levels than WT cells. Cells were treated for five days with either ARI (A) or CAR (B) and the drug levels were determined by LC–MS/MS. Drug metabolites were below the limit of quantitation and could not be determined. Blue and pink symbols denote cells from male and female human donors, respectively. Each symbol corresponds to cell cultures derived from a different individual. Bars correspond to the mean ± SEM; statistical significance: *p < 0.05.