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Febuxostat ameliorated propofol-induced oxidative stress in bEnd.3 brain endothelial cells. Cells were stimulated with 2% propofol in the presence or absence of febuxostat (10, 20 μM) (A) for 24 h. The levels of ROS were measured using dichloro-dihydro-fluorescein diacetate (DCFH-DA) staining; 200 μm. (B) Levels of reduced glutathione (GSH) (####P < 0.0001 vs the vehicle group; **P < 0.01, ***P < 0.001 vs the propofol group, n = 6).
