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Febuxostat inhibited propofol-induced expression and production of the pro-inflammatory chemokines. Cells were stimulated with 2% propofol in the presence or absence of febuxostat (10, 20 μM) for 24 h. (A) mRNA of CXCL-1. (B) mRNA of PDPN. (C) mRNA of CXCL8. (D) Secretions of CXCL-1. (E) Secretions of PDPN. (F) Secretions of CXCL8 (####P < 0.0001 vs the vehicle group; **P < 0.01, ***P < 0.001 vs the propofol group, n = 6).
